GLP-1 therapy

Established evidence

GLP-1 therapy uses medications such as semaglutide and tirzepatide — originally developed for type 2 diabetes — for weight management and metabolic health, with growing cardiovascular evidence. It is prescription-only and requires medical supervision.

Updated 25 June 2026

What GLP-1 therapy involves

GLP-1 receptor agonists (e.g. semaglutide, tirzepatide) are injectable prescription medicines that reduce appetite and improve blood-sugar control. Clinics use them within medically supervised weight-management and metabolic-health programmes.

Evidence and what to consider

Among emerging longevity-adjacent drugs, GLP-1s have unusually strong evidence: a large randomised trial showed semaglutide reduced major cardiovascular events in people with obesity and existing heart disease, and effects on metabolic markers are well documented. Gastrointestinal side effects are common and discontinuation rates are meaningful. These are prescription medicines — they require proper screening, dosing and monitoring by a clinician, not self-sourcing.

Clinics offering GLP-1 therapy

1 clinic

Origin Health Basel

Origin Health Basel

Basel, SwitzerlandMedical
New listing
IV nutrient therapyNAD+ infusionsGLP-1 therapy+7
View Clinic

Showing 1 of 1 clinics

Related treatments

Frequently asked questions

What is GLP-1 therapy?
Treatment with GLP-1 receptor agonist medications (such as semaglutide or tirzepatide) that reduce appetite and improve blood-sugar control, prescribed for weight and metabolic management.
Do GLP-1 drugs have good evidence?
Yes, comparatively strong. A large randomised trial found semaglutide reduced major cardiovascular events in obese adults with existing heart disease, and metabolic benefits are well documented — stronger evidence than most longevity supplements.
What are the side effects?
Gastrointestinal effects such as nausea are common, especially when starting or increasing the dose, and a meaningful share of people stop treatment. A clinician should manage dosing and monitoring.
How much does GLP-1 therapy cost?
Costs depend on the medication, dose and programme. Confirm pricing, monitoring and follow-up with the clinic.
Where can I access GLP-1 therapy?
Browse the verified clinics listed on this page that offer medically supervised programmes, then contact a provider directly.
What does the "Established evidence" rating mean for GLP-1 therapy?
We rate GLP-1 therapy "Established" because it is supported by strong human evidence — large randomised trials or standard medical practice. Our ratings are a simplified mapping of recognised evidence-grading systems such as GRADE and the Oxford CEBM levels of evidence. How we rate evidence